SF3B4 antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: splicing factor 3b, subunit 4, 49kDa
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 50 kDa
Uniprot: Q15427
Gene id: 10262
Background: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence(BPS) in pre-mRNA. Sequence independent binding of SF3A
SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Field of research: Neuroscience, Metabolism, Epigenetics
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: SF3B4
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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