SCAP antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: SREBF chaperone
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 140 kDa, 96 kDa
Uniprot: Q12770
Gene id: 22937
Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP
SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway(By similarity).SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770).
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: SCAP
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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