MAFB antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: v-maf musculoaponeurotic fibrosarcoma oncogene homolog B(avian)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 45 kDa
Uniprot: Q9Y5Q3
Gene id: 9935
Background: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4
80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter(By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Field of research: Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: MAFB
Purification: Immunogen affinity purified
Reactivity: Human, Rat
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