LGR5 antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: leucine-rich repeat-containing G protein-coupled receptor 5
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 92-120kd
Uniprot: O75473
Gene id: 8549
Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and
or maintenance of the adult intestinal stem cells during postembryonic development.
Field of research: Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:100-1:400
Target: LGR5
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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