HEY1 antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: hairy
enhancer-of-split related with YRPW motif 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 33 kDa
Uniprot: Q9Y5J3
Gene id: 23462
Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1
MASH1 and NEUROD4
MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).
Field of research: Cardiovascular, Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200
Target: HEY1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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