FANCD2 antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: Fanconi anemia, complementation group D2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 150-155 kDa
Uniprot: Q9BXW9
Gene id: 2177
Background: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2
FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.The antibody recognize both un-phospho and phospho-Ser(330) of FANCD2.
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200
Target: FANCD2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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