CYP1A1 antibody - 100 µg
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: cytochrome P450, family 1, subfamily A, polypeptide 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 63 kDa
Uniprot: P04798
Gene id: 1543
Background: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Target: CYP1A1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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