Publications


Manzoni G, Marinach C, Topçu S, Briquet S, Grand M, Tolle M, Gransagne M, Lescar J, Andolina C, Franetich JF, Zeisel MB, Huby T, Rubinstein E, Snounou G, Mazier D, Nosten F, Baumert TF, Silvie O.
Plasmodium P36 determines host cell receptor usage during sporozoite invasion.
eLife, 2017 in press.

 

Gonçalves-Carneiro D, McKeating JA and Bailey D.
The microbial sensor SLAMF1 mediates measles virus endocytosis.
J Virology, 2017 in press.

 

Farquhar M, Humphreys I, Rudge SA, Wilson G, Bhattacharya B, Ciaccia M, Hu K, Zhang Q, Mailly L, Reynolds G, Ashcroft M, Balfe P, Baumert TF, Roessler S, Wakelam M JO and McKeating JA.
Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.
J Hepatol. 2017 May;66(5):919-929.

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Appelman MD, Chakraborty A, Protzer U, McKeating JA and van de Graaf, SFJ.
N-glycosylation of the Na+-taurocholate Co-transporting Polypeptide (NTCP) determines its trafficking and stability and is required for hepatitis type B virus entry.
PLoS One. 2017 Jan 26;12(1):e0170419.

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Tientcheu, L.D., Koch, A., Ndengane, M., Andoseh, G., Kampmann, B., Wilkinson, R.J.
Immunological consequences of strain variation within the Mycobacterium tuberculosis complex.
Eur J Immunol. 2017 Mar;47(3):432-445.

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Rockwood, N.S., Pasipanodya, J., Denti, P., Sirgel, F., Lesosky, M., Gumbo, T., Meintjes, G.A., McIlleron, H., Wilkinson, R.J.
Concentration-dependent antagonism and culture conversion in pulmonary tuberculosis.
Clin Infect Dis. 2017 May 15;64(10):1350-1359.

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Bell, L., Peyper, J.M., Garnett, S., Tadokera, R., Wilkinson, R.J., Meintjes, G, Blackburn, J.M.
TB-IRIS: Proteomic analysis of in vitro PBMC responses to Mycobacterium tuberculosis and response modulation by dexamethasone.
Exp Mol Pathol. 2017 Apr;102(2):237-246. doi: 10.1016/j.yexmp.2017.02.008.

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Rockwood, N., Wojno, J., Ghebrekristos, Y., Nicol, M.P., Meintjes, G., Wilkinson, R.J.
Utility of second generation line probe assay (Hain MTBDRplus) directly on 2-month sputa specimens to monitor tuberculosis treatment response.
J Clin Microbiol. 2017 May;55(5):1508-1515.

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Scriven, J.E, Graham, L.M., Schutz, C., Scriba, T.J., Wilkinson, K.A., Wilkinson, R.J., Boulware, D.R., Urban, B.C., Meintjes, G., Lalloo, D.G.
The CSF immune response in HIV-1-associated cryptococcal meningitis: macrophage activation, correlates of disease severity and effect of antiretroviral therapy.
J Acquir Immune Defic Syndr. 2017 Mar 31.

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Koch, A., Brites, D., Stucki, D., Evans, J.C., Seldon, R., Heekes, A., Mulder, N., Nicol, M.P., Oni, T., Warner, D.F., Mizrahi, M., Parkhill, J., Gagneux, S., Martin, D.P., Wilkinson, R.J.
The influence of HIV on the evolution of Mycobacterium tuberculosis.
Mol Biol Evol. 2017 Jul 1;34(7):1654-1668.

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Walker, N.F., Wilkinson, K.A., Meintjes, G., Tezera, L.B., Goliath, R., Peyper J.M., Tadokera, R., Opondo, C., Coussens, A.K., Wilkinson, R.J., Friedland J.S., Elkington, P.T.
Matrix degradation in HIV-1-associated tuberculosis and tuberculosis immune reconstitution inflammatory syndrome: a prospective, observational study.
Clin Infect Dis.
2017 May 5.

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Rockwood, N., Costa, D.L., Amaral, E.P. Du Bruyn, E., Kubler, A., Gil-Santana, L., Fukutani, K.F., Scanga, C.A., Flynn, J.L., Jackson, S.H., Wilkinson, K.A., Bishai, W.R., Sher, A., Wilkinson, R.J., Andrade, B.B.
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression is Dependent on Oxidative Stress and Reflects Treatment Outcomes.
Front Immunol.
2017 May 12;8:542.

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Lim A.I., Li, Y., Lopez-Lastra, S., Stadhouders, R., Paul, F., Cassrouge, A., Serafini, N., Puel, A., Bustamante, J., Surace, L., Masse-Ranson, G., David, E., Stric.k-Marchand, H., Le Bourhis, L., Cocchi, R., Topazio, D., Graziano, P., Muscarella, L.A., Rogge, L., Norel, X., Sallenave, J.-M., Allez, M., Graf, T., Hendriks, R.W., Casanova, J.-L., Amit, I., Yssel, H. and Di Santo, J.P.
Systemic human ILC precursors provide a substrate for tissue ILC differentiation.
Cell. 2017 Mar 9;168(6):1086-1100.

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Koutsoudakis G, Paris de León A, Herrera C, Dorner M, Pérez-Vilaró G, Lyonnais S, Grijalvo S, Eritja R, Meyerhans A, Mirambeau G, Díez J.
Oligonucleotide-lipid conjugates forming G-quadruplex structures are potent and pangenotypic hepatitis C virus entry inhibitors in vitro and ex vivo.
Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02354-16.

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Fletcher NF, Balfe P, and McKeating JA.
TNF superfamily members promote Hepatitis C virus entry through NF-κB and myosin light chain kinase activation.
J Gen Virol. 2017 Mar;98(3):405-412.

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Hedegaard DL, Tully DC, Rowe IA, Reynolds GM, Hu K, Davis C, Wilhem A, Ogilvie CB, Power KA, Tarr A, Kelly D, Allen TM, Balfe P and McKeating JA.
High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization during late stage liver disease.
J Hepatol. 2017 Jan;66(1):28-38.

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Rockwood, N., du Bruyn E., Morris, T., Wilkinson, R.J.
Assessment of treatment response in tuberculosis.
Expert Rev Respir Med. 2016 Jun;10(6):643-54.

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du Bruyn, E., Wilkinson, R.J.
The immune interaction between HIV-1 infection and Mycobacterium tuberculosis.
Microbiol Spectr. 2016 Dec;4(6).

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Horvati, K., Bosze, S., Gideon, H.P., Bacsa, B., Szabo, T.G., Goliath, R.T., Rangaka, M.X., Hudecz, F., Wilkinson, R.J., Wilkinson, K.A.
Population tailored modification of tuberculosis specific interferon-gamma release assay.
J Infect.
2016 Feb;72(2):179-88.

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Scriven, J.E., Graham, L.M., Schutz, C., Scriba, T.J., Wilkinson, R.J., Boulware, D.R., Meintjes, G., Lalloo, D.G., Urban, B.C.
Flow cytometry to assess CSF fungal burden in cryptococcal meningitis.
J Clin Microbiol.
2016 Mar;54(3):802-4.

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Marais, S., Meintjes, G., Lesosky, M., Wilkinson, K.A., Wilkinson, R.J.
IL-17 mediated differences in the pathogenesis of HIV-1-associated tuberculous and cryptococcal meningitis.
AIDS. 2016 Jan 28;30(3):395-404.

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Scriven, J.E., Graham, L.M., Schutz, C., Scriba, T.J., Wilkinson, K.A., Wilkinson, R.J., Boulware, D.R., Urban, B.C., Lalloo, D.G., Meintjes, G.
A glucuronoxylomannan-associated immune signature, characterized by monocyte deactivation and raised IL-10, is a predictor of death in cryptococcal meningitis.
J Infect Dis. 2016 Jun 1;213(11):1725-34.

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Lerner, T.R., de Souza Carvalho-Wodarz, C., Repnik, U., Russell, M., Borel, S., Diedrich, C.R., Rohde, M., Wainwright, H., Collinson, L.M., Wilkinson, R.J., Griffiths, G., Gutierrez, M.G.
Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis.
J Clin Invest. 2016 Mar 1;126(3):1093-108.

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Riou, C., Strickland, S., Soares, A.P., Corleis, B., Kwon, D.S., Wherry, E.J., Wilkinson, R.J., Burgers, W.A.
HIV skews the lineage-defining transcriptional profile of Mycobacterium tuberculosis-specific CD4+ T cells.
J Immunol. 2016 Apr 1;196(7):3006-18.

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Diedrich, C.R., O’Hern, J., Wilkinson, R.J.
HIV-1 and the Mycobacterium tuberculosis granuloma: a systematic review and meta-analysis.
Tuberculosis (Edinb). 2016 May;98:62-76.

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Wilkinson, K.A., Oni, T., Gideon, H.P., Goliath, R.T., Wilkinson, R.J., Riou, C.R.
Activation profile of Mycobacterium tuberculosis-specific CD4+ T cells reflects disease activity, irrespective of HIV status.
Am J Respir Crit Care Med. 2016 Jun 1;193(11):1307-10.

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Bangani, N., Nakiwala, J., Martineau, A.R., Wilkinson, R.J., Wilkinson, K.A., Lowe, D.M.
HIV-1 infection impairs CD16 and CD35 mediated opsonophagocytosis of M. tuberculosis by human neutrophils.
J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):263-267.

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Diedrich, C.R., O’Hern, J., Gutierrez, M.G., Allie, N., Papier, P., Meintjes, G., Coussens, A.K., Wainwright, H., Wilkinson, R.J.
Relationship between HIV-1 co-infection, IL-10, and M. tuberculosis in human lymph node granulomas.
J Infect Dis. 2016 Nov 1;214(9):1309-1318.

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Rockwood, N.N., Meintjes, G., Chirehwa, M., Wiesner, L., McIlleron, H., Wilkinson, R.J., and Denti, P.
HIV-1 co-infection does not reduce exposure to rifampicin, isoniazid, and pyrazinamide in South African tuberculosis outpatients.
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6050-9.

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Esmail, H., Lai R., P-J., Lesosky, M., Wilkinson, K.A., Graham, C.M., Coussens, A.K.,  Oni, T., Warwick, J.M., Said-Hartley, Q., Koegelenberg, C.F., Walzl, G.,  Flynn, J.L.,  Young, D.B., Barry 3rd, C.E., O’Garra, A., Wilkinson, R.J.
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.
Nat Med. 2016 Oct;22(10):1090-1093.

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Bana, T.M., Lesosky, M., Pepper, D.J., van der Plas, H., Schutz, C., Goliath, R.T., Morroni, C., Mendelson, M., Maartens, G., Wilkinson, R.J., Meintjes, G.
Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors.
BMC Infect Dis.
2016 Sep 27;16(1):518.

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Riou, C., Bunjun, R., Müller, T.L., Kiravu, A., Ginbot, Z., Oni, T., Goliath, R., Wilkinson, R.J., and Burgers, W.A.
Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.
Tuberculosis (Edinb). 2016 Dec;101:25-30.

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Desombere I, Fafi-Kremer S, Van Houtte F, Pessaux P, Farhoudi A, Heydmann L, Verhoye L, Beattie S, McKeating JA, Leroux-Roels G, Baumert TF, Patel AH and Meuleman P.
Monoclonal anti-envelope antibody AP33 protects against an in vivo hepatitis C virus quasispecies challenge.
Hepatology. 2016 Apr;63(4):1120-34.

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Verrier ER, Colpitts CC, Zona L, Bach C, Heydmann L, Xiao F, Thumann C, Schuster C, Sureau C, McKeating JA, Hoshida Y, Zeisel MB and Baumert TF.
Solute carrier NTCP regulates expression of innate antiviral immune responses targeting viral cell entry into hepatocytes.
Cell Rep. 2016 Oct 25;17(5):1357-1368.

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Lim, A.-I., Menegatti, S., Bustamante, J., Le Bourhis, L., Allez, M., Rogge, L., Casanova, J.-L., Yssel, H. and Di Santo, J.P.
IL-12 drives functional plasticity of human group 2 innate lymphoid cells.
J Exp Med. 2016 Apr 4;213(4):569-83.

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Li, Y., Mention, J.-J., Court, N., Masse-Ranson, G., Toubert, A., Spits, H., Legrand, N., Corcuff, E., Strick-Marchand, H. and Di Santo, J.P.
A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.
Eur J Immunol. 2016 May;46(5):1291-9.

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Zhang YH, Zhao Y, Rajapaksa US, Lawrence TM, Peng YC, Liu J, Xu K, Hu K, Qin L, Liu N, Sun H, Yan HP, Repapi E, Rowland-Jones S, Thimme R, McKeating JA, Dong T.
A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort.
PLoS One. 2016 Jul 25;11(7):e0158037.

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Lai, R. P-J., Meintjes, G., Wilkinson, R.J.
HIV-1 tuberculosis associated immune reconstitution inflammatory syndrome.
Semin Immunopathol. 2016 Mar;38(2):185-98.  

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Horvati K, Bosze S, Gideon HP, Bacsa B, Szabo TG, Goliath RT, Rangaka MX, Hudecz F, Wilkinson RJ, Wilkinson KA.
Population tailored modification of tuberculosis specific interferon-gamma release assay.
J Infect. 2016 Feb;72(2):179-88.

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Wilson, G.K., Farquhar, M.J., Meredith, L., Dharwan, A., Mitry, R., Balfe, P., and McKeating. J.A. Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection.
J Gen Virol. 2015 Jun;96(Pt 6):1369-73.

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Risco-Castillo V, Topçu S, Marinach C, Manzoni G, Bigorgne AE, Briquet S, Baudin X, Lebrun M, Dubremetz JF, Silvie O. Malaria sporozoites traverse cells within transient vacuoles.
Cell Host & Microbe 2015 Nov 11; Volume 18, 5:593-603.

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Matthews K, Deffur A, Ntsekhe M, Syed F, Russell JBW, Tibazarwa K, Wolske J, Brink J, Mayosi BM, Wilkinson RJ, Wilkinson KA.
A compartmentalized profibrotic immune response characterises pericardial tuberculosis, irrespective of HIV-1 infection.
Am J Respir Crit Care Med. 2015 Dec 15;192(12):1518-21.

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Lai RP, Meintjes G., Wilkinson RJ.
HIV-1 tuberculosis associated immune reconstitution inflammatory syndrome.
Semin Immunopathol. 2016 Mar;38(2):185-98.

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Meredith LW, Hu K, Cheng X, Howard CR, Baumert TF, Balfe P, van de Graaf KF, Protzer U, McKeating JA.
Lentiviral hepatitis B pseudotype entry requires NTCP and additional hepatocyte-specific factors.
J Gen Virol. 2016 Jan;97(1):121-7.

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Lawn SD and Wilkinson RJ.
Antiretroviral therapy and prevention of HIV-associated tuberculosis.
Lancet HIV. 2015 Jun;2(6):e221-2. doi: 10.1016/S2352-3018(15)00081-8. Epub 2015 May 17.

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Risco-Castillo V, Topçu S, Marinach C, Manzoni G, Bigorgne AE, Briquet S, Baudin X, Lebrun M, Dubremetz JF, Silvie O.
Malaria sporozoites traverse cells within transient vacuoles.
Cell Host & Microbe 2015 Nov 11; Volume 18, 5:593-603.


Mathiesen CK, Prentoe J, Meredith LW, Jensen TB, Krarup H, McKeating JA, Gottwein JM, Bukh J.
Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant.
J. Virol. 2015 Aug;89(15):7758-75. doi: 10.1128/JVI.00039-15. Epub 2015 May 20.

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Fletcher NF, Humphreys E, Jennings E, Osburn W, Lissauer S, Wilson GK, van IJzendoorn SC, Baumert TF, Balfe P, Afford S, McKeating JA.
Hepatitis C virus infection of cholangiocarcinoma cell lines.
J Gen Virol. 2015 Jun;96(Pt 6):1380-8. doi: 10.1099/vir.0.000090. Epub 2015 Feb 20.

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Stax MJ, Mouser EEIM, van Montfort T, Sanders RW, de Vries HJC, Dekker HL. C Herrera, Speijer D, Pollakis G, Paxton WA
Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4(+) T-Lymphocytes.
PLoS One. 2015 Mar 20;10(3):e0122020. doi: 10.1371/journal.pone.0122020. eCollection 2015

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Rockwood N., Abdullahi L.H., Wilkinson, R.J., Meintjes G.
Risk factors for acquired rifamycin and isoniazid resistance: a systematic review and meta-analysis.
PLoS One. 2015 Sep 25;10(9):e0139017. doi: 10.1371/journal.pone.0139017. eCollection 2015.

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Lai, RP, Meintjes G, Wilkinson KA, Graham CM, Marais S, Van der Plas H, Deffur A, Schutz C, Bloom C, Munagala I, Anguiano E, Goliath G, Maartens G, Banchereau J, Chaussabel D, O’Garra, A, Wilkinson R.J.
HIV-Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Is Characterized by Toll-Like-Receptor And Inflammasome Signaling.
Nat Commun. 2015 Sep 24;6:8451. doi: 10.1038/ncomms9451.

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Lowe DM, Bangani N, Goliath RT, Kampmann B, Wilkinson KA, Wilkinson RJ, Martineau AR.
Effect of antiretroviral therapy on HIV-mediated impairment of the neutrophil antimycobacterial response.
Ann Am Thorac Soc. 2015 Nov;12(11):1627-37. doi: 10.1513/AnnalsATS.201507-463OC.

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Subbarao S., Wilkinson KA, van Halsema CL, Rao SS, Boyles T, Utay NS, Wilkinson RJ, Meintjes G.
Raised venous lactate and markers of intestinal translocation are associated with mortality amongst in-patients with HIV-associated TB in rural South Africa.
J Acquir Immune 2015 Dec 1;70(4):406-13. doi: 10.1097/QAI.0000000000000763.

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Coussens AK, Naudé C, Goliath RT, Chaplin G, Wilkinson RJ, Jablonski NG.
High-dose vitamin D3 reduces deficiency due to low UVB exposure and limits HIV replication in urban Southern Africans.
Proc Natl Acad Sci USA. 2015 Jun 30;112(26):8052-7. doi: 10.1073/pnas.1500909112. Epub 2015 Jun 15. Reviews and editorials.

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Namale PE, Abdullahi LH, Fine S, Kamkuemah M, Wilkinson RJ, Meintjes G.
Paradoxical TB-IRIS in HIV-infected adults: a systematic review and meta-analysis.
Future Microbiol. 2015;10(6):1077-99. doi: 10.2217/fmb.15.9.

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Heim MH, Thimme R.
Innate and adaptive immune responses in HCV infections.
J Hepatol. 2014 Nov;61(1 Suppl): S14-25.

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Stax MJ, Mouser EE, van Montfort T, Sanders RW, de Vries HJ, Dekker HL, Herrera C, Speijer D, Pollakis G, Paxton WA.
Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4+ T-Lymphocytes.
PLoS One. 2015 Mar 20;10(3):e0122020.

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Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D.
Obtaining the Plasmodium falciparum full life cycle and observations on the P. ovale liver stages in humanized mice.
Nat Comm. 2015 Jul 24;6:7690.

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Oni T, Youngblood E, Boulle A, McGrath N, Wilkinson RJ, Levitt, NS.
Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa - a cross sectional study.
BMC Infect Dis. 2015 Jan 17;15:20.

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Wilkinson KA, Walker NF, Meintjes G, Deffur A, Nicol MP, Skolimowska KH, Matthews K, Tadokera R, Seldon RR, Maartens G, Rangaka MX, Besra G, Wilkinson RJ.
Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.
J Immunol. 2015 Feb 15;194(4):1748-54.

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Jones CE, Hesseling A, Tena-Coki NG, Scriba TJ, Chegou, NN, Kidd M. Wilkinson, R.J., Kampmann, B.
The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to Bacille Calmette-Guérin vaccination.
AIDS. 2015 Jan 14;29(2):155-65.

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Walker NF, Scriven J, Meintjes G, Wilkinson RJ.
Immune reconstitution inflammatory syndrome in HIV-infected patients.
HIV AIDS (Auckl). 2015 Feb 12;7:49-64.

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Koch A and Wilkinson RJ.
The road to drug resistance in Mycobacterium tuberculosis.
Genome Biol. 2014 Nov 13;15(11):520.

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Deffur A, Wilkinson RJ, Coussens AK.
Tricks to Translating TB Transcriptomics.
Ann Transl Med. 2015 May;3(Suppl 1):S43.

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Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, Masse-Ranson G, Corcuff E, Ahodantin J, Weijer K, Spits H, Kremsdorf D, Di Santo JP.
A novel mouse model for stable engraftment of a human immune system and human hepatocytes.
PLoS One. 2015 Mar 17;10(3):e0119820.

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Risco-Castillo V, Topçu S, Son O, Briquet S, Manzoni G, Silvie O.
CD81 is required for rhoptry discharge during host cell invasion by Plasmodium yoelii sporozoites.
Cell Microbiol. 2014 Oct;16(10):1533-48.

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